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SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators

Coronaviruses (CoVs) of genera α, β, γ, and δ encode proteins that have a PDZ-binding motif (PBM) consisting of the last four residues of the envelope (E) protein (PBM core). PBMs may bind over 400 cellular proteins containing PDZ domains (an acronym formed by the combination of the first letter of...

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Detalles Bibliográficos
Autores principales: Honrubia, Jose M., Gutierrez-Álvarez, Javier, Sanz-Bravo, Alejandro, González-Miranda, Ezequiel, Muñoz-Santos, Diego, Castaño-Rodriguez, Carlos, Wang, Li, Villarejo-Torres, Marta, Ripoll-Gómez, Jorge, Esteban, Ana, Fernandez-Delgado, Raul, Sánchez-Cordón, Pedro José, Oliveros, Juan Carlos, Perlman, Stanley, McCray, Paul B., Sola, Isabel, Enjuanes, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973274/
https://www.ncbi.nlm.nih.gov/pubmed/36625656
http://dx.doi.org/10.1128/mbio.03136-22