Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation

Transcription of herpes simplex virus 1 (HSV-1) immediate early (IE) genes is controlled at multiple levels by the cellular transcriptional coactivator, HCF-1. HCF-1 is complexed with epigenetic factors that prevent silencing of the viral genome upon infection, transcription factors that drive initi...

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Detalles Bibliográficos
Autores principales: Arbuckle, Jesse H., Vogel, Jodi L., Efstathiou, Stacey, Kristie, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973298/
https://www.ncbi.nlm.nih.gov/pubmed/36692302
http://dx.doi.org/10.1128/mbio.03542-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973298/
https://www.ncbi.nlm.nih.gov/pubmed/36692302
http://dx.doi.org/10.1128/mbio.03542-22

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