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N(6)-Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections

Mitogen-activated protein kinases (MAPKs) play critical roles in the induction of numerous cytokines, chemokines, and inflammatory mediators that mobilize the immune system to counter pathogenic infections. Dual-specificity phosphatase 1 (DUSP1) is a member of the dual-specificity phosphatases that...

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Detalles Bibliográficos
Autores principales: Feng, Jian, Meng, Wen, Chen, Luping, Zhang, Xinquan, Markazi, Ashley, Yuan, Weiming, Huang, Yufei, Gao, Shou-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973302/
https://www.ncbi.nlm.nih.gov/pubmed/36625590
http://dx.doi.org/10.1128/mbio.03349-22