Watson-Crick Base-Pairing Requirements for ssDNA Recognition and Processing in Replication-Initiating HUH Endonucleases

Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication. These functions are mediated by covalent linkage of the Rep to its substrate post cleavage. Here, we describe the structures of the en...

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Detalles Bibliográficos
Autores principales: Smiley, Adam T., Tompkins, Kassidy J., Pawlak, Matthew R., Krueger, August J., Evans, Robert L., Shi, Ke, Aihara, Hideki, Gordon, Wendy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973303/
https://www.ncbi.nlm.nih.gov/pubmed/36541758
http://dx.doi.org/10.1128/mbio.02587-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973303/
https://www.ncbi.nlm.nih.gov/pubmed/36541758
http://dx.doi.org/10.1128/mbio.02587-22

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