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Watson-Crick Base-Pairing Requirements for ssDNA Recognition and Processing in Replication-Initiating HUH Endonucleases
Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication. These functions are mediated by covalent linkage of the Rep to its substrate post cleavage. Here, we describe the structures of the en...
Autores principales: | Smiley, Adam T., Tompkins, Kassidy J., Pawlak, Matthew R., Krueger, August J., Evans, Robert L., Shi, Ke, Aihara, Hideki, Gordon, Wendy R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973303/ https://www.ncbi.nlm.nih.gov/pubmed/36541758 http://dx.doi.org/10.1128/mbio.02587-22 |
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