Cargando…

Watson-Crick Base-Pairing Requirements for ssDNA Recognition and Processing in Replication-Initiating HUH Endonucleases

Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication. These functions are mediated by covalent linkage of the Rep to its substrate post cleavage. Here, we describe the structures of the en...

Descripción completa

Detalles Bibliográficos
Autores principales: Smiley, Adam T., Tompkins, Kassidy J., Pawlak, Matthew R., Krueger, August J., Evans, Robert L., Shi, Ke, Aihara, Hideki, Gordon, Wendy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973303/
https://www.ncbi.nlm.nih.gov/pubmed/36541758
http://dx.doi.org/10.1128/mbio.02587-22

Ejemplares similares