Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

The purine-derived signaling molecules c-di-AMP and (p)ppGpp control mecA/PBP2a-mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise the possibility that purine availability can control antibiotic susceptibility. Consistent with this, exogenous guanosine and xanth...

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Detalles Bibliográficos
Autores principales: Nolan, Aaron C., Zeden, Merve S., Kviatkovski, Igor, Campbell, Christopher, Urwin, Lucy, Corrigan, Rebecca M., Gründling, Angelika, O’Gara, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973305/
https://www.ncbi.nlm.nih.gov/pubmed/36507833
http://dx.doi.org/10.1128/mbio.02478-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973305/
https://www.ncbi.nlm.nih.gov/pubmed/36507833
http://dx.doi.org/10.1128/mbio.02478-22

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