A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies

HIV-1 and its SIV precursors share a broadly neutralizing antibody (bNAb) epitope in variable loop 2 (V2) at the envelope glycoprotein (Env) trimer apex. Here, we tested the immunogenicity of germ line-targeting versions of a chimpanzee SIV (SIVcpz) Env in human V2-apex bNAb heavy-chain precursor-ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Bibollet-Ruche, Frederic, Russell, Ronnie M., Ding, Wenge, Liu, Weimin, Li, Yingying, Wagh, Kshitij, Wrapp, Daniel, Habib, Rumi, Skelly, Ashwin N., Roark, Ryan S., Sherrill-Mix, Scott, Wang, Shuyi, Rando, Juliette, Lindemuth, Emily, Cruickshank, Kendra, Park, Younghoon, Baum, Rachel, Carey, John W., Connell, Andrew Jesse, Li, Hui, Giorgi, Elena E., Song, Ge S., Ding, Shilei, Finzi, Andrés, Newman, Amanda, Hernandez, Giovanna E., Machiele, Emily, Cain, Derek W., Mansouri, Katayoun, Lewis, Mark G., Montefiori, David C., Wiehe, Kevin J., Alam, S. Munir, Teng, I-Ting, Kwong, Peter D., Andrabi, Raiees, Verkoczy, Laurent, Burton, Dennis R., Korber, Bette T., Saunders, Kevin O., Haynes, Barton F., Edwards, Robert J., Shaw, George M., Hahn, Beatrice H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973348/
https://www.ncbi.nlm.nih.gov/pubmed/36629414
http://dx.doi.org/10.1128/mbio.03370-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973348/
https://www.ncbi.nlm.nih.gov/pubmed/36629414
http://dx.doi.org/10.1128/mbio.03370-22

Ejemplares similares