Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy

The absence of T cells in the tumor microenvironment of solid tumors is a major barrier to cancer immunotherapy efficacy. Oncolytic viruses, including reovirus type 3 Dearing (Reo), can recruit CD8(+) T cells to the tumor and thereby enhance the efficacy of immunotherapeutic strategies that depend o...

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Detalles Bibliográficos
Autores principales: Groeneveldt, Christianne, van Ginkel, Jurriaan Q., Kinderman, Priscilla, Sluijter, Marjolein, Griffioen, Lisa, Labrie, Camilla, van den Wollenberg, Diana J.M., Hoeben, Rob C., van der Burg, Sjoerd H., ten Dijke, Peter, Hawinkels, Lukas J.A.C., van Hall, Thorbald, van Montfoort, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973387/
https://www.ncbi.nlm.nih.gov/pubmed/36860656
http://dx.doi.org/10.1158/2767-9764.CRC-23-0019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973387/
https://www.ncbi.nlm.nih.gov/pubmed/36860656
http://dx.doi.org/10.1158/2767-9764.CRC-23-0019

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