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Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory–Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand
T cells with a stem cell memory (T(SCM)) phenotype provide long-term and potent antitumor effects for T-cell transfer therapies. Although various methods for the induction of T(SCM)-like cells in vitro have been reported, few methods generate T(SCM)-like cells from effector/exhausted T cells. We hav...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973402/ https://www.ncbi.nlm.nih.gov/pubmed/36860911 http://dx.doi.org/10.1158/2767-9764.CRC-21-0034 |