Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory–Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand

T cells with a stem cell memory (T(SCM)) phenotype provide long-term and potent antitumor effects for T-cell transfer therapies. Although various methods for the induction of T(SCM)-like cells in vitro have been reported, few methods generate T(SCM)-like cells from effector/exhausted T cells. We hav...

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Detalles Bibliográficos
Autores principales: Ando, Makoto, Kondo, Taisuke, Tomisato, Wataru, Ito, Minako, Shichino, Shigeyuki, Srirat, Tanakorn, Mise-Omata, Setsuko, Nakagawara, Kensuke, Yoshimura, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973402/
https://www.ncbi.nlm.nih.gov/pubmed/36860911
http://dx.doi.org/10.1158/2767-9764.CRC-21-0034

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