Cargando…

ALK5 Inhibition of Subconjunctival Scarring From Glaucoma Surgery: Effects of SB-431542 Compared to Mitomycin C in Human Tenon's Capsule Fibroblasts

PURPOSE: The gold standard for managing postoperative ocular fibrosis in glaucoma surgery is the chemotherapeutic mitomycin C (MMC) despite its association with significant adverse effects. This study compares in vitro the antifibrotic efficacy and cytotoxicity of the small-molecule TGFβ1 inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teplitsky, Jack E., Vinokurtseva, Anastasiya, Armstrong, James J., Denstedt, James, Liu, Hong, Hutnik, Cindy M. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9973532/ https://www.ncbi.nlm.nih.gov/pubmed/36826843 http://dx.doi.org/10.1167/tvst.12.2.31

Ejemplares similares

The Pro-Fibrotic Behavior of Human Tenon’s Capsule Fibroblasts in Medically Treated Glaucoma Patients
por: Trelford, Charles B, et al.
Publicado: (2020)

Comparative evaluation of outcomes of novel approach of subconjunctival Mitomycin C (MMC) injection at the end of trabeculectomy versus intraTenon injection of MMC prior to the initial conjunctival incision – A pilot study
por: Gupta, Ved Prakash, et al.
Publicado: (2022)

SPARC is expressed in scars of the Tenon’s capsule and mediates scarring properties of human Tenon’s fibroblasts in vitro
por: Fuchshofer, Rudolf, et al.
Publicado: (2011)

Is canaloplasty with mitomycin c a safe procedure in myopic glaucoma?
por: Dooling, Vivienne, et al.
Publicado: (2022)

The Effect of CHIR 99021, a Glycogen Synthase Kinase-3β Inhibitor, on Transforming Growth Factor β-Induced Tenon Fibrosis
por: Lee, Sang Yeop, et al.
Publicado: (2021)

Deep sclerectomy and trabeculectomy augmented with Mitomycin C: 2-year post-operative outcomes
por: Dwivedi, Rahul, et al.
Publicado: (2021)

Inhibitory Effects of 3′,4′-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts
por: Fan Gaskin, Jennifer C., et al.
Publicado: (2022)

Exact matching of trabectome-mediated ab interno trabeculectomy to conventional trabeculectomy with mitomycin C followed for 2 years
por: Strzalkowska, A., et al.
Publicado: (2020)

SPARC Levels Modulate the Capacity of Mitomycin to Inhibit the Proliferation of Human Tenon's Capsule Fibroblasts
por: Guo, Yuanyuan, et al.
Publicado: (2020)

The outcomes of a low-cost, non-valved glaucoma drainage device using mitomycin-C: 1-year results
por: Awad-Allah, Mo’mena Ahmad A., et al.
Publicado: (2023)

An Ilomastat-CD Eye Drop Formulation to Treat Ocular Scarring
por: Mohamed-Ahmed, Abeer H. A., et al.
Publicado: (2017)

Impact of Inhaled and Intranasal Corticosteroids Exposure on the Risk of Ocular Hypertension and Glaucoma: A Systematic Review and Meta-Analysis
por: Vinokurtseva, Anastasiya, et al.
Publicado: (2022)

Epigenetic Modification Prevents Excessive Wound Healing and Scar Formation After Glaucoma Filtration Surgery
por: Sharma, Ajay, et al.
Publicado: (2016)

Comparison of analgesia and akinesia between sub-Tenon’s capsule anesthesia and trans-Tenon’s capsule retrobulbar anesthesia in vitrectomy
por: Nomura, Ryoko, et al.
Publicado: (2021)

Augmenting trabeculectomy in glaucoma with subconjunctival mitomycin C versus subconjunctival 5-fluorouracil: a randomized clinical trial
por: Mostafaei, Ali
Publicado: (2011)

The TGF-β/Smad Pathway Inhibitor SB431542 Enhances The Antitumor Effect Of Radiofrequency Ablation On Bladder Cancer Cells
por: Zhou, Hong-qing, et al.
Publicado: (2019)

Trabeculectomy Tenon Advancement Technique May Reduce Bleb-Related Infections
por: Mambo, Yuki, et al.
Publicado: (2023)

Combination of SB431542, Chir9901, and Bpv as a novel supplement in the culture of umbilical cord blood hematopoietic stem cells
por: Zarrabi, Morteza, et al.
Publicado: (2020)

Topical Mitomycin-C versus Subconjunctival 5-Fluorouracil for Management of Bleb Failure
por: Pakravan, Mohammad, et al.
Publicado: (2011)

Subconjunctival bevacizumab to augment trabeculectomy with mitomycin C in the management of failed glaucoma surgery
por: Saeed, Ahmed M, et al.
Publicado: (2014)

TGF-β Inhibitor SB431542 Promotes the Differentiation of Induced Pluripotent Stem Cells and Embryonic Stem Cells into Mesenchymal-Like Cells
por: Leyendecker Junior, Alessander
Publicado: (2018)

Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma
por: Chaudhary, Priya, et al.
Publicado: (2022)

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost
por: Roddy, Gavin W., et al.
Publicado: (2017)

Effect of Body Position on Intraocular Pressure (IOP), Intracranial Pressure (ICP), and Translaminar Pressure (TLP) Via Continuous Wireless Telemetry in Nonhuman Primates (NHPs)
por: Jasien, Jessica V., et al.
Publicado: (2020)

Diurnal Cycle of Translaminar Pressure in Nonhuman Primates Quantified With Continuous Wireless Telemetry
por: Jasien, Jessica V., et al.
Publicado: (2020)

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents
por: Roy Chowdhury, Uttio, et al.
Publicado: (2017)

Visual Crowding in Glaucoma
por: Ogata, Nara G., et al.
Publicado: (2019)

Radiosensitization of Non-Small Cell Lung Cancer Cells by Inhibition of TGF-β1 Signaling With SB431542 Is Dependent on p53 Status
por: Zhao, Yifan, et al.
Publicado: (2016)

Aqueous Angiography–Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes
por: Huang, Alex S., et al.
Publicado: (2016)

Racial Differences in the Association of Anterior Lamina Cribrosa Surface Depth and Glaucoma Severity in the African Descent and Glaucoma Evaluation Study (ADAGES)
por: Girkin, Christopher A., et al.
Publicado: (2019)

Racial Differences in the Rate of Change in Anterior Lamina Cribrosa Surface Depth in the African Descent and Glaucoma Evaluation Study
por: Girkin, Christopher A., et al.
Publicado: (2021)

Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma Patients
por: Gustavsson, Simon T., et al.
Publicado: (2023)

Oxidative Stress–Related Molecular Biomarker Candidates for Glaucoma
por: Hondur, Gözde, et al.
Publicado: (2017)

TGF-β Small Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis
por: Davies, Michael R., et al.
Publicado: (2016)

In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon’s fibroblasts: comparisons with mitomycin C
por: Seet, Li-Fong, et al.
Publicado: (2012)

Glaucoma Surgery with Soaked Sponges with Mitomycin C vs Sub-Tenon Injection: Short-term Outcomes
por: Guimarães, Maria EV, et al.
Publicado: (2019)

Anti-scarring effects of conbercept on human Tenon’s fibroblasts: comparisons with bevacizumab
por: Zuo, Lei, et al.
Publicado: (2023)

Ologen implant versus mitomycin C in combined trabeculectomy and phacoemulsification
por: Paul, Chandrima, et al.
Publicado: (2022)

RNA Sequencing of Lens Capsular Epithelium Implicates Novel Pathways in Pseudoexfoliation Syndrome
por: Mullany, Sean, et al.
Publicado: (2022)

Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells
por: Madhu, Vedavathi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3p1395lu2k59511ke2kmn19m3l