TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis

The transcription factor p63 guards genome integrity in the female germline, and its mutations have been reported in patients with premature ovarian insufficiency (POI). However, the precise contribution of the TP63 gene to the pathogenesis of POI needs to be further determined. Here, in 1,030 Chine...

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Detalles Bibliográficos
Autores principales: Huang, Chengzi, Zhao, Simin, Yang, Yajuan, Guo, Ting, Ke, Hanni, Mi, Xin, Qin, Yingying, Chen, Zi-Jiang, Zhao, Shidou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974095/
https://www.ncbi.nlm.nih.gov/pubmed/36856110
http://dx.doi.org/10.1172/JCI162315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974095/
https://www.ncbi.nlm.nih.gov/pubmed/36856110
http://dx.doi.org/10.1172/JCI162315

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