SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes

The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometric data were collected from research kidney biopsies donated by young persons with type 2 diabetes (T2D), aged 12 to 21 years, and healthy c...

Descripción completa

Detalles Bibliográficos
Autores principales: Schaub, Jennifer A., AlAkwaa, Fadhl M., McCown, Phillip J., Naik, Abhijit S., Nair, Viji, Eddy, Sean, Menon, Rajasree, Otto, Edgar A., Demeke, Dawit, Hartman, John, Fermin, Damian, O’Connor, Christopher L., Subramanian, Lalita, Bitzer, Markus, Harned, Roger, Ladd, Patricia, Pyle, Laura, Pennathur, Subramaniam, Inoki, Ken, Hodgin, Jeffrey B., Brosius, Frank C., Nelson, Robert G., Kretzler, Matthias, Bjornstad, Petter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974101/
https://www.ncbi.nlm.nih.gov/pubmed/36637914
http://dx.doi.org/10.1172/JCI164486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974101/
https://www.ncbi.nlm.nih.gov/pubmed/36637914
http://dx.doi.org/10.1172/JCI164486

Ejemplares similares