Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

The prolyl-tRNA synthetase (PRS) is a validated drug target for febrifugine and its synthetic analog halofuginone (HFG) against multiple apicomplexan parasites including Plasmodium falciparum and Toxoplasma gondii. Here, a novel ATP-mimetic centered on 1-(pyridin-4-yl) pyrrolidin-2-one (PPL) scaffol...

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Detalles Bibliográficos
Autores principales: Yogavel, Manickam, Bougdour, Alexandre, Mishra, Siddhartha, Malhotra, Nipun, Chhibber-Goel, Jyoti, Bellini, Valeria, Harlos, Karl, Laleu, Benoît, Hakimi, Mohamed-Ali, Sharma, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974123/
https://www.ncbi.nlm.nih.gov/pubmed/36854028
http://dx.doi.org/10.1371/journal.ppat.1011124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974123/
https://www.ncbi.nlm.nih.gov/pubmed/36854028
http://dx.doi.org/10.1371/journal.ppat.1011124

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