Liquid–liquid phase separation of amyloid-β oligomers modulates amyloid fibrils formation

Soluble amyloid-β oligomers (AβOs) are proposed to instigate and mediate the pathology of Alzheimer’s disease, but the mechanisms involved are not clear. In this study, we reported that AβOs can undergo liquid–liquid phase separation (LLPS) to form liquid-like droplets in vitro. We determined that A...

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Detalles Bibliográficos
Autores principales: Gui, Xinrui, Feng, Shuang, Li, Zilong, Li, Yanyan, Reif, Bernd, Shi, Bingyang, Niu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974441/
https://www.ncbi.nlm.nih.gov/pubmed/36682493
http://dx.doi.org/10.1016/j.jbc.2023.102926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974441/
https://www.ncbi.nlm.nih.gov/pubmed/36682493
http://dx.doi.org/10.1016/j.jbc.2023.102926

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