Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases

Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial roles in cellular metabolism. These multi-subunit enzyme complexes use lipoic arms covalently attached to their E2 subunits to transfer...

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Detalles Bibliográficos
Autores principales: Seim, Gretchen L., John, Steven V., Arp, Nicholas L., Fang, Zixiang, Pagliarini, David J., Fan, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974485/
https://www.ncbi.nlm.nih.gov/pubmed/36266351
http://dx.doi.org/10.1038/s41589-022-01153-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974485/
https://www.ncbi.nlm.nih.gov/pubmed/36266351
http://dx.doi.org/10.1038/s41589-022-01153-w

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