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Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases

Pyruvate dehydrogenase complex (PDHC) and oxoglutarate dehydrogenase complex (OGDC), which belong to the mitochondrial α-ketoacid dehydrogenase family, play crucial roles in cellular metabolism. These multi-subunit enzyme complexes use lipoic arms covalently attached to their E2 subunits to transfer...

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Detalles Bibliográficos
Autores principales:	Seim, Gretchen L., John, Steven V., Arp, Nicholas L., Fang, Zixiang, Pagliarini, David J., Fan, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974485/ https://www.ncbi.nlm.nih.gov/pubmed/36266351 http://dx.doi.org/10.1038/s41589-022-01153-w

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