Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery

G-protein metallochaperone MeaB in bacteria [methylmalonic aciduria type A (MMAA) in humans] is responsible for facilitating the delivery of adenosylcobalamin (AdoCbl) to methylmalonyl-CoA mutase (MCM), the only AdoCbl-dependent enzyme in humans. Genetic defects in the switch III region of MMAA lead...

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Detalles Bibliográficos
Autores principales: Vaccaro, Francesca A., Born, David A., Drennan, Catherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974510/
https://www.ncbi.nlm.nih.gov/pubmed/36787360
http://dx.doi.org/10.1073/pnas.2214085120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974510/
https://www.ncbi.nlm.nih.gov/pubmed/36787360
http://dx.doi.org/10.1073/pnas.2214085120

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