Revealing charge heterogeneity of stressed trastuzumab at the subunit level

Trastuzumab is known to be heterogeneous in terms of charge. Stressing trastuzumab under physiological conditions (pH 7.4 and 37 °C) increases charge heterogeneity further. Separation of charge variants of stressed trastuzumab at the intact protein level is challenging due to increasing complexity m...

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Detalles Bibliográficos
Autores principales: Spanov, Baubek, Baartmans, Bas, Olaleye, Oladapo, Nicolardi, Simone, Govorukhina, Natalia, Wuhrer, Manfred, van de Merbel, Nico C., Bischoff, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974696/
https://www.ncbi.nlm.nih.gov/pubmed/36693954
http://dx.doi.org/10.1007/s00216-023-04547-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974696/
https://www.ncbi.nlm.nih.gov/pubmed/36693954
http://dx.doi.org/10.1007/s00216-023-04547-4

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