Towards multiomic analysis of oral mucosal pathologies

Oral mucosal pathologies comprise an array of diseases with worldwide prevalence and medical relevance. Affecting a confined space with crucial physiological and social functions, oral pathologies can be mutilating and drastically reduce quality of life. Despite their relevance, treatment for these...

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Autores principales: Einhaus, Jakob, Han, Xiaoyuan, Feyaerts, Dorien, Sunwoo, John, Gaudilliere, Brice, Ahmad, Somayeh H., Aghaeepour, Nima, Bruckman, Karl, Ojcius, David, Schürch, Christian M., Gaudilliere, Dyani K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974703/
https://www.ncbi.nlm.nih.gov/pubmed/36790488
http://dx.doi.org/10.1007/s00281-022-00982-0
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author Einhaus, Jakob
Han, Xiaoyuan
Feyaerts, Dorien
Sunwoo, John
Gaudilliere, Brice
Ahmad, Somayeh H.
Aghaeepour, Nima
Bruckman, Karl
Ojcius, David
Schürch, Christian M.
Gaudilliere, Dyani K.
author_facet Einhaus, Jakob
Han, Xiaoyuan
Feyaerts, Dorien
Sunwoo, John
Gaudilliere, Brice
Ahmad, Somayeh H.
Aghaeepour, Nima
Bruckman, Karl
Ojcius, David
Schürch, Christian M.
Gaudilliere, Dyani K.
author_sort Einhaus, Jakob
collection PubMed
description Oral mucosal pathologies comprise an array of diseases with worldwide prevalence and medical relevance. Affecting a confined space with crucial physiological and social functions, oral pathologies can be mutilating and drastically reduce quality of life. Despite their relevance, treatment for these diseases is often far from curative and remains vastly understudied. While multiple factors are involved in the pathogenesis of oral mucosal pathologies, the host’s immune system plays a major role in the development, maintenance, and resolution of these diseases. Consequently, a precise understanding of immunological mechanisms implicated in oral mucosal pathologies is critical (1) to identify accurate, mechanistic biomarkers of clinical outcomes; (2) to develop targeted immunotherapeutic strategies; and (3) to individualize prevention and treatment approaches. Here, we review key elements of the immune system’s role in oral mucosal pathologies that hold promise to overcome limitations in current diagnostic and therapeutic approaches. We emphasize recent and ongoing multiomic and single-cell approaches that enable an integrative view of these pathophysiological processes and thereby provide unifying and clinically relevant biological signatures.
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spelling pubmed-99747032023-03-02 Towards multiomic analysis of oral mucosal pathologies Einhaus, Jakob Han, Xiaoyuan Feyaerts, Dorien Sunwoo, John Gaudilliere, Brice Ahmad, Somayeh H. Aghaeepour, Nima Bruckman, Karl Ojcius, David Schürch, Christian M. Gaudilliere, Dyani K. Semin Immunopathol Review Oral mucosal pathologies comprise an array of diseases with worldwide prevalence and medical relevance. Affecting a confined space with crucial physiological and social functions, oral pathologies can be mutilating and drastically reduce quality of life. Despite their relevance, treatment for these diseases is often far from curative and remains vastly understudied. While multiple factors are involved in the pathogenesis of oral mucosal pathologies, the host’s immune system plays a major role in the development, maintenance, and resolution of these diseases. Consequently, a precise understanding of immunological mechanisms implicated in oral mucosal pathologies is critical (1) to identify accurate, mechanistic biomarkers of clinical outcomes; (2) to develop targeted immunotherapeutic strategies; and (3) to individualize prevention and treatment approaches. Here, we review key elements of the immune system’s role in oral mucosal pathologies that hold promise to overcome limitations in current diagnostic and therapeutic approaches. We emphasize recent and ongoing multiomic and single-cell approaches that enable an integrative view of these pathophysiological processes and thereby provide unifying and clinically relevant biological signatures. Springer Berlin Heidelberg 2023-02-15 2023 /pmc/articles/PMC9974703/ /pubmed/36790488 http://dx.doi.org/10.1007/s00281-022-00982-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Einhaus, Jakob
Han, Xiaoyuan
Feyaerts, Dorien
Sunwoo, John
Gaudilliere, Brice
Ahmad, Somayeh H.
Aghaeepour, Nima
Bruckman, Karl
Ojcius, David
Schürch, Christian M.
Gaudilliere, Dyani K.
Towards multiomic analysis of oral mucosal pathologies
title Towards multiomic analysis of oral mucosal pathologies
title_full Towards multiomic analysis of oral mucosal pathologies
title_fullStr Towards multiomic analysis of oral mucosal pathologies
title_full_unstemmed Towards multiomic analysis of oral mucosal pathologies
title_short Towards multiomic analysis of oral mucosal pathologies
title_sort towards multiomic analysis of oral mucosal pathologies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974703/
https://www.ncbi.nlm.nih.gov/pubmed/36790488
http://dx.doi.org/10.1007/s00281-022-00982-0
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