PAMAM-G4 protect the N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) and maintain its antiproliferative effects on MCF-7

Our work group designed and synthesized a promissory compound N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA). The HO-AAVPA is a HDAC1 inhibitor and antiproliferative in cancer cell lines. However, HO-AAVPA is poor water solubility and enzymatically metabolized. In this work, the fourth-generatio...

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Detalles Bibliográficos
Autores principales: Ortiz-Morales, Alma Alicia, García-Vázquez, Juan Benjamín, Fragoso-Vázquez, Manuel Jonathan, Rosales-Hernández, Martha Cecilia, Fragoso-Morales, Leticia Guadalupe, Estrada-Pérez, Alan Rubén, Correa-Basurto, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974963/
https://www.ncbi.nlm.nih.gov/pubmed/36854957
http://dx.doi.org/10.1038/s41598-023-30144-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9974963/
https://www.ncbi.nlm.nih.gov/pubmed/36854957
http://dx.doi.org/10.1038/s41598-023-30144-7

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