Structures and conformational dynamics of DNA minidumbbells in pyrimidine-rich repeats associated with neurodegenerative diseases

Expansions of short tandem repeats (STRs) are associated with approximately 50 human neurodegenerative diseases. These pathogenic STRs are prone to form non-B DNA structure, which has been considered as one of the causative factors for repeat expansions. Minidumbbell (MDB) is a relatively new type o...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuan, Wan, Liqi, Ngai, Cheuk Kit, Wang, Yang, Lam, Sik Lok, Guo, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975016/
https://www.ncbi.nlm.nih.gov/pubmed/36874156
http://dx.doi.org/10.1016/j.csbj.2023.02.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975016/
https://www.ncbi.nlm.nih.gov/pubmed/36874156
http://dx.doi.org/10.1016/j.csbj.2023.02.010

Ejemplares similares