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A clustering linear combination method for multiple phenotype association studies based on GWAS summary statistics

There is strong evidence showing that joint analysis of multiple phenotypes in genome-wide association studies (GWAS) can increase statistical power when detecting the association between genetic variants and human complex diseases. We previously developed the Clustering Linear Combination (CLC) met...

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Detalles Bibliográficos
Autores principales: Wang, Meida, Cao, Xuewei, Zhang, Shuanglin, Sha, Qiuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975197/
https://www.ncbi.nlm.nih.gov/pubmed/36854754
http://dx.doi.org/10.1038/s41598-023-30415-3