Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease

The causal variants and genes underlying thousands of cardiac GWAS signals have yet to be identified. Here, we leverage spatiotemporal information on 966 RNA-seq cardiac samples and perform an expression quantitative trait locus (eQTL) analysis detecting eQTLs considering both eGenes and eIsoforms....

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Detalles Bibliográficos
Autores principales: D’Antonio, Matteo, Nguyen, Jennifer P., Arthur, Timothy D., Matsui, Hiroko, D’Antonio-Chronowska, Agnieszka, Frazer, Kelly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975214/
https://www.ncbi.nlm.nih.gov/pubmed/36854752
http://dx.doi.org/10.1038/s41467-023-36638-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975214/
https://www.ncbi.nlm.nih.gov/pubmed/36854752
http://dx.doi.org/10.1038/s41467-023-36638-2

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