Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

More than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-suppressor gene. Being a member of the Polycomb repressive deubiquitinating (PR-DUB) complex, BAP1 loss results in an altered epigenome, which may create new vulnerabilities that remain largely unknown. Here, w...

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Detalles Bibliográficos
Autores principales: Pandey, Gaurav Kumar, Landman, Nick, Neikes, Hannah K., Hulsman, Danielle, Lieftink, Cor, Beijersbergen, Roderick, Kolluri, Krishna Kalyan, Janes, Sam M., Vermeulen, Michiel, Badhai, Jitendra, van Lohuizen, Maarten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975229/
https://www.ncbi.nlm.nih.gov/pubmed/36657447
http://dx.doi.org/10.1016/j.xcrm.2022.100915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975229/
https://www.ncbi.nlm.nih.gov/pubmed/36657447
http://dx.doi.org/10.1016/j.xcrm.2022.100915

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