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Enolpyruvate transferase MurAA(A149E), identified during adaptation of Enterococcus faecium to daptomycin, increases stability of MurAA–MurG interaction

Daptomycin (DAP) is an antibiotic frequently used as a drug of last resort against vancomycin-resistant enterococci. One of the major challenges when using DAP against vancomycin-resistant enterococci is the emergence of resistance, which is mediated by the cell-envelope stress system LiaFSR. Indeed...

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Detalles Bibliográficos
Autores principales: Zhou, Yue, Utama, Budi, Pratap, Shivendra, Supandy, Adeline, Song, Xinhao, Tran, Truc T., Mehta, Heer H., Arias, Cesar A., Shamoo, Yousif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975281/
https://www.ncbi.nlm.nih.gov/pubmed/36649910
http://dx.doi.org/10.1016/j.jbc.2023.102912