Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis

OBJECTIVE: To summarize the single-centre experience of Ex vivo Liver Resection and Autotransplantation (ELRA) to treat end-stage hepatic alveolar echinococcosis (HAE). METHODS: Retrospective analysis of clinical data and follow-up data of 13 patients admitted to the Affiliated Hospital of Qinghai U...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Jiaqi, Chen, Xiaobin, Hou, Lizhao, Wang, Haijiu, Zhou, Ying, Pang, Mingquan, YangDan, CaiRang, Wang, Zhixin, Fan, Haining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975350/
https://www.ncbi.nlm.nih.gov/pubmed/36874451
http://dx.doi.org/10.3389/fsurg.2023.1089788
_version_ 1784898858035183616
author Yuan, Jiaqi
Chen, Xiaobin
Hou, Lizhao
Wang, Haijiu
Zhou, Ying
Pang, Mingquan
YangDan, CaiRang
Wang, Zhixin
Fan, Haining
author_facet Yuan, Jiaqi
Chen, Xiaobin
Hou, Lizhao
Wang, Haijiu
Zhou, Ying
Pang, Mingquan
YangDan, CaiRang
Wang, Zhixin
Fan, Haining
author_sort Yuan, Jiaqi
collection PubMed
description OBJECTIVE: To summarize the single-centre experience of Ex vivo Liver Resection and Autotransplantation (ELRA) to treat end-stage hepatic alveolar echinococcosis (HAE). METHODS: Retrospective analysis of clinical data and follow-up data of 13 patients admitted to the Affiliated Hospital of Qinghai University from January 2015 to December 1, 2020, with the Ex vivo Liver Resection and Autotransplantation for hepatic alveolar echinococcosis. RESULT: 13 patients underwent successful total/ semi-ex-vivo liver resection combined with Ex vivo Liver Resection and Autotransplantation with no intra-operative deaths. the median standard liver volume was 1,118 ml (1,085–1,206.5 ml); the median residual liver volume was 634 ml (526.5–1,338 ml); The median weight of the autograft was 845.8 g (619.5–1,020.5 g), the median operation time was 14.5 h (11.5–16.15 h); the median anhepatic period time was 290 min (257–312.5 min). The median intraoperative blood loss was 1,900 ml (1,300–3,500 ml); the median number of erythrocyte suspensions entered was 7.5 u (6–9u). The median length of hospital stay was 32 days (24–40 days). Postoperative complications occurred in 9 patients during hospitalization,with 7 patients graded at grade III or higher by Clavien-Dindo; 4 patients died postoperatively. 1 patient had recurrent abdominal distension with massive thoracoabdominal fluid and coagulation dysfunction 8 months after surgery and was considered to have small liver syndrome. 1 patient developed HAE recurrence during the follow-up, which was considered intraoperative incisional implantation. CONCLUSION: ELRA is one of the most valuable therapeutic measures for the treatment of end-stage complicated hepatic alveolar echinococcosis. Precise preoperative assessment of liver function, individualized intraoperative duct reconstruction, and precise management of the postoperative disease can achieve better treatment results.
format Online
Article
Text
id pubmed-9975350
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99753502023-03-02 Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis Yuan, Jiaqi Chen, Xiaobin Hou, Lizhao Wang, Haijiu Zhou, Ying Pang, Mingquan YangDan, CaiRang Wang, Zhixin Fan, Haining Front Surg Surgery OBJECTIVE: To summarize the single-centre experience of Ex vivo Liver Resection and Autotransplantation (ELRA) to treat end-stage hepatic alveolar echinococcosis (HAE). METHODS: Retrospective analysis of clinical data and follow-up data of 13 patients admitted to the Affiliated Hospital of Qinghai University from January 2015 to December 1, 2020, with the Ex vivo Liver Resection and Autotransplantation for hepatic alveolar echinococcosis. RESULT: 13 patients underwent successful total/ semi-ex-vivo liver resection combined with Ex vivo Liver Resection and Autotransplantation with no intra-operative deaths. the median standard liver volume was 1,118 ml (1,085–1,206.5 ml); the median residual liver volume was 634 ml (526.5–1,338 ml); The median weight of the autograft was 845.8 g (619.5–1,020.5 g), the median operation time was 14.5 h (11.5–16.15 h); the median anhepatic period time was 290 min (257–312.5 min). The median intraoperative blood loss was 1,900 ml (1,300–3,500 ml); the median number of erythrocyte suspensions entered was 7.5 u (6–9u). The median length of hospital stay was 32 days (24–40 days). Postoperative complications occurred in 9 patients during hospitalization,with 7 patients graded at grade III or higher by Clavien-Dindo; 4 patients died postoperatively. 1 patient had recurrent abdominal distension with massive thoracoabdominal fluid and coagulation dysfunction 8 months after surgery and was considered to have small liver syndrome. 1 patient developed HAE recurrence during the follow-up, which was considered intraoperative incisional implantation. CONCLUSION: ELRA is one of the most valuable therapeutic measures for the treatment of end-stage complicated hepatic alveolar echinococcosis. Precise preoperative assessment of liver function, individualized intraoperative duct reconstruction, and precise management of the postoperative disease can achieve better treatment results. Frontiers Media S.A. 2023-02-15 /pmc/articles/PMC9975350/ /pubmed/36874451 http://dx.doi.org/10.3389/fsurg.2023.1089788 Text en © 2023 Yuan, Chen, Hou, Wang, Zhou, Pang, YangDan, Wang and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Yuan, Jiaqi
Chen, Xiaobin
Hou, Lizhao
Wang, Haijiu
Zhou, Ying
Pang, Mingquan
YangDan, CaiRang
Wang, Zhixin
Fan, Haining
Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis
title Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis
title_full Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis
title_fullStr Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis
title_full_unstemmed Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis
title_short Single-center experience of Ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis
title_sort single-center experience of ex vivo liver resection and autotransplantation for complex hepatic alveolar echinoccosis
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975350/
https://www.ncbi.nlm.nih.gov/pubmed/36874451
http://dx.doi.org/10.3389/fsurg.2023.1089788
work_keys_str_mv AT yuanjiaqi singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT chenxiaobin singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT houlizhao singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT wanghaijiu singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT zhouying singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT pangmingquan singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT yangdancairang singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT wangzhixin singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis
AT fanhaining singlecenterexperienceofexvivoliverresectionandautotransplantationforcomplexhepaticalveolarechinoccosis