Cargando…

Calcium influx, oxidative stress, and apoptosis induced by TRPV1 in chronic myeloid leukemia cells: Synergistic effects with imatinib

Introduction: Calcium flux is the master second messenger that influences the proliferation–apoptosis balance. The ability of calcium flux alterations to reduce cell growth makes ion channels interesting targets for therapy. Among all, we focused on transient receptor potential vanilloid 1, a ligand...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maggi, Federica, Morelli, Maria Beatrice, Aguzzi, Cristina, Zeppa, Laura, Nabissi, Massimo, Polidori, Carlo, Santoni, Giorgio, Amantini, Consuelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975599/ https://www.ncbi.nlm.nih.gov/pubmed/36876044 http://dx.doi.org/10.3389/fmolb.2023.1129202

Ejemplares similares

The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib
por: Maggi, Federica, et al.
Publicado: (2022)

The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer
por: Marinelli, Oliviero, et al.
Publicado: (2020)

Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update
por: Maggi, Federica, et al.
Publicado: (2021)

Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
por: Morelli, Maria Beatrice, et al.
Publicado: (2022)

Evening Primrose Oil Improves Chemotherapeutic Effects in Human Pancreatic Ductal Adenocarcinoma Cell Lines—A Preclinical Study
por: Zeppa, Laura, et al.
Publicado: (2022)

Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-Mediated Stress-Induced Neurodegenerative Diseases
por: Santoni, Giorgio, et al.
Publicado: (2020)

Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
por: Liberati, Sonia, et al.
Publicado: (2014)

Biological Function of PD-L2 and Correlation With Overall Survival in Type II Endometrial Cancer
por: Marinelli, Oliviero, et al.
Publicado: (2020)

Post-transcriptional regulation of 5'-untranslated regions of human Transient Receptor Potential Vanilloid type-1 (TRPV-1) channels: role in the survival of glioma patients
por: Nabissi, Massimo, et al.
Publicado: (2016)

Correction: Liberati, S., et al. Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression. Cells 2014, 3, 112–128
por: Liberati, Sonia, et al.
Publicado: (2014)

The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity
por: Amantini, Consuelo, et al.
Publicado: (2017)

Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients
por: Santoni, Giorgio, et al.
Publicado: (2022)

Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines
por: Luongo, Margherita, et al.
Publicado: (2020)

The Controversial Role of PD-1 and Its Ligands in Gynecological Malignancies
por: Marinelli, Oliviero, et al.
Publicado: (2019)

Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses
por: Santoni, Giorgio, et al.
Publicado: (2020)

Coexpression of TRPML1 and TRPML2 Mucolipin Channels Affects the Survival of Glioblastoma Patients
por: Santoni, Giorgio, et al.
Publicado: (2022)

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons
por: Santoni, Giorgio, et al.
Publicado: (2015)

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients
por: Morelli, Maria Beatrice, et al.
Publicado: (2022)

ERK Phosphorylation Regulates the Aml1/Runx1 Splice Variants and the TRP Channels Expression during the Differentiation of Glioma Stem Cell Lines
por: Santoni, Giorgio, et al.
Publicado: (2021)

“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses
por: Santoni, Giorgio, et al.
Publicado: (2018)

Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient’s Survival
por: Morelli, Maria Beatrice, et al.
Publicado: (2019)

Exploring treatment with Ribociclib alone or in sequence/combination with Everolimus in ER(+)HER2(−)Rb wild-type and knock-down in breast cancer cell lines
por: Marinelli, Oliviero, et al.
Publicado: (2020)

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner
por: Amantini, Consuelo, et al.
Publicado: (2016)

Knock-Down of Mucolipin 1 Channel Promotes Tumor Progression and Invasion in Human Glioblastoma Cell Lines
por: Santoni, Giorgio, et al.
Publicado: (2021)

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells
por: Morelli, Maria Beatrice, et al.
Publicado: (2015)

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner
por: Morelli, Maria Beatrice, et al.
Publicado: (2016)

The Transient Receptor Potential Vanilloid Type-2 (TRPV2) Ion Channels in Neurogenesis and Gliomagenesis: Cross-Talk between Transcription Factors and Signaling Molecules
por: Santoni, Giorgio, et al.
Publicado: (2019)

Mechanosensation and Mechanotransduction in Natural Killer Cells
por: Santoni, Giorgio, et al.
Publicado: (2021)

A Closer Look at Anandamide Interaction With TRPV1
por: Muller, Chante, et al.
Publicado: (2020)

The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses
por: Santoni, Giorgio, et al.
Publicado: (2013)

Editorial: Calcium signaling in cancer immunity
por: Amantini, Consuelo, et al.
Publicado: (2023)

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression
por: Morelli, Maria Beatrice, et al.
Publicado: (2016)

Glomerular endothelial glycocalyx-derived heparan sulfate inhibits glomerular leukocyte influx and attenuates experimental glomerulonephritis
por: Maciej-Hulme, Marissa L., et al.
Publicado: (2023)

The Mucolipin TRPML2 Channel Enhances the Sensitivity of Multiple Myeloma Cell Lines to Ibrutinib and/or Bortezomib Treatment
por: Santoni, Giorgio, et al.
Publicado: (2022)

Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators
por: Morales, Paula, et al.
Publicado: (2022)

Role of TRPV1 ion channel in cervical squamous cell carcinoma genesis
por: Wang, Zhenming, et al.
Publicado: (2022)

Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival
por: Amantini, Consuelo, et al.
Publicado: (2019)

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration
por: Nabissi, Massimo, et al.
Publicado: (2016)

The Prognostic Value of the Circulating Tumor Cell-Based Four mRNA Scoring System: A New Non-Invasive Setting for the Management of Bladder Cancer
por: Amantini, Consuelo, et al.
Publicado: (2022)

TRPV4 is a Prognostic Biomarker that Correlates with the Immunosuppressive Microenvironment and Chemoresistance of Anti-Cancer Drugs
por: Wang, Kai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a65iq1tsr2f5eucqjqms3pslp0