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Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal

53BP1 (TP53-binding protein 1), a key player in DNA double-strand break repair, has a classical bipartite nuclear localization signal (NLS) of sequence 1666-GKRKLITSEEERSPAKRGRKS-1686 that binds to importin-α, a nuclear import adaptor protein. Nucleoporin Nup153 is involved in nuclear import of 53BP...

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Detalles Bibliográficos
Autor principal: Matsuura, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975678/
https://www.ncbi.nlm.nih.gov/pubmed/36875212
http://dx.doi.org/10.1016/j.dib.2023.108988