Germline TFAM levels regulate mitochondrial DNA copy number and mutant heteroplasmy in C. elegans

The mitochondrial genome (mtDNA) is packaged into discrete protein-DNA complexes called nucleoids. mtDNA packaging factor TFAM (mitochondrial transcription factor-A) promotes nucleoid compaction and is required for mtDNA replication. Here, we investigate how changing TFAM levels affects mtDNA in the...

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Detalles Bibliográficos
Autores principales: Schwartz, Aaron Z.A., Nance, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975812/
https://www.ncbi.nlm.nih.gov/pubmed/36873298
http://dx.doi.org/10.17912/micropub.biology.000727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975812/
https://www.ncbi.nlm.nih.gov/pubmed/36873298
http://dx.doi.org/10.17912/micropub.biology.000727

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