Cargando…

Germline TFAM levels regulate mitochondrial DNA copy number and mutant heteroplasmy in C. elegans

The mitochondrial genome (mtDNA) is packaged into discrete protein-DNA complexes called nucleoids. mtDNA packaging factor TFAM (mitochondrial transcription factor-A) promotes nucleoid compaction and is required for mtDNA replication. Here, we investigate how changing TFAM levels affects mtDNA in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schwartz, Aaron Z.A., Nance, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Caltech Library 2023
Materias:	New Finding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9975812/ https://www.ncbi.nlm.nih.gov/pubmed/36873298 http://dx.doi.org/10.17912/micropub.biology.000727

Ejemplares similares

Localization of HIM-19 in the C. elegans germline
por: Roelens, Baptiste, et al.
Publicado: (2022)

A single copy transgenic mutant FUS strain reproduces age-dependent ALS phenotypes in C. elegans
por: Labarre, Audrey, et al.
Publicado: (2021)

Copulation defective mutants of C. elegans
por: Hajdu-Cronin, Yvonne M., et al.
Publicado: (2017)

sart-3 functions to regulate germline sex determination in C. elegans .
por: Furuta, Tokiko, et al.
Publicado: (2023)

Long-read sequencing infers a mechanism for copy number variation of template for alternative lengthening of telomeres in a wild C. elegans strain
por: Lee, Bo Yun, et al.
Publicado: (2022)

Characterization of larval growth in C. elegans cuticle mutants
por: Nyaanga, Joy, et al.
Publicado: (2022)

rol-6 and dpy-10 C. elegans mutants have normal mitochondrial function after normalizing to delayed development
por: Sparling, A. Clare, et al.
Publicado: (2023)

The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone in C. elegans hermaphrodites
por: Aprison, Erin Z., et al.
Publicado: (2022)

Caenorhabditis elegans daf-7 mutants exhibit burrowing behavior
por: López-Puebla, Araceli, et al.
Publicado: (2019)

Isolation of intragenic suppressor of tsp-15-splicing mutant in Caenorhabditis elegans
por: Moribe, Hiroki, et al.
Publicado: (2019)

GFP::PCN-1 does not reliably mark S phase in C. elegans adult germline progenitor zone cells
por: Uruta, Tokiko, et al.
Publicado: (2018)

Screening for C. elegans male copulation-defective mutants by the mating plug phenotype
por: Liu, Katharine, et al.
Publicado: (2017)

C. elegans VWA-8 is a mitochondrial protein
por: Zhu, Ming, et al.
Publicado: (2020)

A T231E Mutant that Mimics Pathologic Phosphorylation of Tau in Alzheimer’s disease Causes Activation of the Mitochondrial Unfolded Protein Response in C. elegans touch neurons
por: Guha, Sanjib, et al.
Publicado: (2020)

Enhanced pentylenetetrazole sensitivity in a C. elegans mutant associated with DNM1 encephalopathy
por: Vaji, Madeline A., et al.
Publicado: (2020)

Comparison of the efficiency of TIR1 transgenes to provoke auxin induced LAG-1 degradation in Caenorhabditis elegans germline stem cells
por: Chen, Jian, et al.
Publicado: (2020)

Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in Caenorhabditis elegans
por: Chávez-Pérez, Carlos, et al.
Publicado: (2021)

GABA Receptor mutant gbb-1 accelerates morphological aging of GABA neurons in Caenorhabditis elegans
por: Dhillon, I., et al.
Publicado: (2018)

aptf-1 mutants are primarily defective in head movement quiescence during C. elegans sleep
por: Robinson, Bryan, et al.
Publicado: (2019)

Pharyngeal pumping rate does not reflect lifespan extension in C. elegans transgenerational longevity mutants
por: Croft, Jaime C., et al.
Publicado: (2023)

C. elegans rab-18 mutants display reduced lipid content under fed and fasted conditions
por: Ratemi, Zakaria, et al.
Publicado: (2019)

Minimum number of synaptic vesicles for the initiation of a single action potential at C. elegans neuromuscular junction
por: Chen, Lili, et al.
Publicado: (2020)

Three C. elegans srf-6 mutants carry nsy-1 mutations (srf-6 is nsy-1 I)
por: Van Sciver, Nicholas D., et al.
Publicado: (2019)

copa-1 mutants experience heightened endoplasmic reticulum stress sensitivity in a C. elegans COPA Syndrome model
por: Larkin, Kerry A., et al.
Publicado: (2023)

Tetramethylpyrazine blocks TFAM degradation and up-regulates mitochondrial DNA copy number by interacting with TFAM
por: Lan, Linhua, et al.
Publicado: (2017)

Paternal mitochondria from an rmd-2, rmd-3, rmd-6 triple mutant are properly positioned in the C. elegans zygote
por: Juanico, Iris Y, et al.
Publicado: (2021)

C. elegans dkf-1 (Protein Kinase D1) mutants have age-dependent defects in locomotion and neuromuscular transmission
por: Johnson, James R., et al.
Publicado: (2023)

OP50, a bacterial strain conventionally used as food for laboratory maintenance of C. elegans, is a biofilm formation defective mutant
por: Arata, Yukinobu, et al.
Publicado: (2020)

tmem-258 is dispensable for both nuclear anchorage and migration in C. elegans
por: Gregory, Ellen Faith, et al.
Publicado: (2020)

Increased expression of pgph-1, T23F2.4, and cyp-14A5 in C. elegans dpy-7 mutants and by high salt
por: Scolaro, Gabrielle, et al.
Publicado: (2019)

An AMPK biosensor for Caenorhabditis elegans
por: Carman, Lynly, et al.
Publicado: (2022)

The C. elegans Casein Kinase II is associated with meiotic DNA in fertilized oocytes
por: Yim, Nahyun, et al.
Publicado: (2022)

Effect of DMSO on lifespan and physiology in C. elegans : Implications for use of DMSO as a solvent for compound delivery
por: AlOkda, Abdelrahman, et al.
Publicado: (2022)

Role of GLD-3 in suppression of the germline stem cell fate.
por: Mohammad, Ariz, et al.
Publicado: (2020)

ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
por: Aprison, Erin Z., et al.
Publicado: (2022)

Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants.
por: Lins, Jeremy, et al.
Publicado: (2023)

C. elegans CYLC-2 localizes to sperm
por: Krauchunas, Amber R, et al.
Publicado: (2020)

Lipopolysaccharide stimulates egg laying in Caenorhabditis elegans
por: Leung, Angela Ching-Yee, et al.
Publicado: (2020)

Estimation of C. elegans cell- and tissue volumes
por: Froehlich, Jonathan J, et al.
Publicado: (2021)

Hypoxia induces food leaving in C. elegans
por: Pu, Longjun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vo45m7tri7btngusts38efmie5