Combination of In Silico and In Vitro Screening to Identify Novel Glutamate Carboxypeptidase II Inhibitors

[Image: see text] Glutamate carboxypeptidase II (GCPII) is a metalloprotease implicated in neurological diseases and prostate oncology. While several classes of potent GCPII-specific inhibitors exist, the development of novel active scaffolds with different pharmacological profiles remains a challen...

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Detalles Bibliográficos
Autores principales: Temml, Veronika, Kollár, Jakub, Schönleitner, Theresa, Höll, Anna, Schuster, Daniela, Kutil, Zsófia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976286/
https://www.ncbi.nlm.nih.gov/pubmed/36799916
http://dx.doi.org/10.1021/acs.jcim.2c01269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976286/
https://www.ncbi.nlm.nih.gov/pubmed/36799916
http://dx.doi.org/10.1021/acs.jcim.2c01269

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