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Combination of In Silico and In Vitro Screening to Identify Novel Glutamate Carboxypeptidase II Inhibitors

[Image: see text] Glutamate carboxypeptidase II (GCPII) is a metalloprotease implicated in neurological diseases and prostate oncology. While several classes of potent GCPII-specific inhibitors exist, the development of novel active scaffolds with different pharmacological profiles remains a challen...

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Detalles Bibliográficos
Autores principales:	Temml, Veronika, Kollár, Jakub, Schönleitner, Theresa, Höll, Anna, Schuster, Daniela, Kutil, Zsófia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976286/ https://www.ncbi.nlm.nih.gov/pubmed/36799916 http://dx.doi.org/10.1021/acs.jcim.2c01269

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