Deep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our comprehensio...

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Detalles Bibliográficos
Autores principales: Anziani, Paul, Becker, Jérémie, Mignon, Charlotte, Arnaud-Barbe, Nadège, Courtois, Virginie, Izac, Marie, Pizzato, Romain, Abi-Ghanem, Joséphine, Tran, Viet-Dung, Sarafian, Magali, Bunescu, Andrei, Garnier, Dominique, Abachin, Eric, Renauld-Mongénie, Geneviève, Guyard, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976334/
https://www.ncbi.nlm.nih.gov/pubmed/36876086
http://dx.doi.org/10.3389/fmicb.2023.1036386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976334/
https://www.ncbi.nlm.nih.gov/pubmed/36876086
http://dx.doi.org/10.3389/fmicb.2023.1036386

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