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Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation

BACKGROUND & AIMS: Hepatocyte transplantation has emerged as a possible treatment option for end-stage liver disease. However, an important obstacle to therapeutic success is the low level of engraftment and proliferation of transplanted hepatocytes, which do not survive long enough to exert the...

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Detalles Bibliográficos
Autores principales: Jiang, Mengmeng, Guo, Ren, Ai, Yan, Wang, Gang, Tang, Peilan, Jia, Xiaohui, He, Bingqing, Yuan, Qianting, Xie, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976449/
https://www.ncbi.nlm.nih.gov/pubmed/36873420
http://dx.doi.org/10.1016/j.jhepr.2023.100670