Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition

Anti-CRISPR proteins are encoded by phages to inhibit the CRISPR-Cas systems of the hosts. AcrIIC5 inhibits several naturally high-fidelity type II-C Cas9 enzymes, including orthologs from Neisseria meningitidis (Nme1Cas9) and Simonsiella muelleri (SmuCas9). Here, we solve the structure of AcrIIC5 i...

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Detalles Bibliográficos
Autores principales: Sun, Wei, Zhao, Xiaolong, Wang, Jinlong, Yang, Xiaoqi, Cheng, Zhi, Liu, Shuo, Wang, Jiuyu, Sheng, Gang, Wang, Yanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976890/
https://www.ncbi.nlm.nih.gov/pubmed/36744495
http://dx.doi.org/10.1093/nar/gkad052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976890/
https://www.ncbi.nlm.nih.gov/pubmed/36744495
http://dx.doi.org/10.1093/nar/gkad052

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