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Recovering false negatives in CRISPR fitness screens with JLOE
It is widely accepted that pooled library CRISPR knockout screens offer greater sensitivity and specificity than prior technologies in detecting genes whose disruption leads to fitness defects, a critical step in identifying candidate cancer targets. However, the assumption that CRISPR screens are s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976895/ https://www.ncbi.nlm.nih.gov/pubmed/36727483 http://dx.doi.org/10.1093/nar/gkad046 |