Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics

Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic tissues remains challenging. Prior attempts to imp...

Descripción completa

Detalles Bibliográficos
Autores principales: Finicle, Brendan T, Eckenstein, Kazumi H, Revenko, Alexey S, Anderson, Brooke A, Wan, W Brad, McCracken, Alison N, Gil, Daniel, Fruman, David A, Hanessian, Stephen, Seth, Punit P, Edinger, Aimee L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976930/
https://www.ncbi.nlm.nih.gov/pubmed/36727438
http://dx.doi.org/10.1093/nar/gkad023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976930/
https://www.ncbi.nlm.nih.gov/pubmed/36727438
http://dx.doi.org/10.1093/nar/gkad023

Ejemplares similares