MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy

Pyruvate is an essential metabolite produced by glycolysis in the cytosol and must be transported across the inner mitochondrial membrane into the mitochondrial matrix, where it is oxidized to fuel mitochondrial respiration. Pyruvate import is performed by the mitochondrial pyruvate carrier (MPC), a...

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Detalles Bibliográficos
Autores principales: Pujol, Claire, Lebigot, Elise, Gaignard, Pauline, Galai, Said, Kraoua, Ichraf, Bault, Jean-Philippe, Dard, Rodolphe, Youssef-Turki, Ilhem Ben, Omar, Souheil, Boutron, Audrey, Wai, Timothy, Slama, Abdelhamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976959/
https://www.ncbi.nlm.nih.gov/pubmed/36417180
http://dx.doi.org/10.1093/brain/awac444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976959/
https://www.ncbi.nlm.nih.gov/pubmed/36417180
http://dx.doi.org/10.1093/brain/awac444

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