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In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease
Humans accumulate with age the dark-brown pigment neuromelanin inside specific neuronal groups. Neurons with the highest neuromelanin levels are particularly susceptible to degeneration in Parkinson’s disease, especially dopaminergic neurons of the substantia nigra, the loss of which leads to charac...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976971/ https://www.ncbi.nlm.nih.gov/pubmed/36717986 http://dx.doi.org/10.1093/brain/awac445 |