In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease

Humans accumulate with age the dark-brown pigment neuromelanin inside specific neuronal groups. Neurons with the highest neuromelanin levels are particularly susceptible to degeneration in Parkinson’s disease, especially dopaminergic neurons of the substantia nigra, the loss of which leads to charac...

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Detalles Bibliográficos
Autores principales: Gonzalez-Sepulveda, Marta, Compte, Joan, Cuadros, Thais, Nicolau, Alba, Guillard-Sirieix, Camille, Peñuelas, Núria, Lorente-Picon, Marina, Parent, Annabelle, Romero-Giménez, Jordi, Cladera-Sastre, Joana M, Laguna, Ariadna, Vila, Miquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976971/
https://www.ncbi.nlm.nih.gov/pubmed/36717986
http://dx.doi.org/10.1093/brain/awac445

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