Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia

SPG15 is a hereditary spastic paraplegia subtype caused by mutations in Spastizin, a protein encoded by the ZFYVE26 gene. Spastizin is involved in autophagosome maturation and autophagic lysosome reformation and SPG15-related mutations lead to autophagic lysosome reformation defects with lysosome en...

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Detalles Bibliográficos
Autores principales: Vantaggiato, Chiara, Orso, Genny, Guarato, Giulia, Brivio, Francesca, Napoli, Barbara, Panzeri, Elena, Masotti, Simona, Santorelli, Filippo Maria, Lamprou, Maria, Gumeni, Sentiljana, Clementi, Emilio, Bassi, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976989/
https://www.ncbi.nlm.nih.gov/pubmed/36029068
http://dx.doi.org/10.1093/brain/awac308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976989/
https://www.ncbi.nlm.nih.gov/pubmed/36029068
http://dx.doi.org/10.1093/brain/awac308

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