Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM

The pathogenesis of MYBPC3-associated hypertrophic cardiomyopathy (HCM) is still unresolved. In our HCM patient cohort, a large and well-characterized population carrying the MYBPC3:c772G>A variant (p.Glu258Lys, E258K) provides the unique opportunity to study the basic mechanisms of MYBPC3-HCM wi...

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Detalles Bibliográficos
Autores principales: Pioner, Josè Manuel, Vitale, Giulia, Steczina, Sonette, Langione, Marianna, Margara, Francesca, Santini, Lorenzo, Giardini, Francesco, Lazzeri, Erica, Piroddi, Nicoletta, Scellini, Beatrice, Palandri, Chiara, Schuldt, Maike, Spinelli, Valentina, Girolami, Francesca, Mazzarotto, Francesco, van der Velden, Jolanda, Cerbai, Elisabetta, Tesi, Chiara, Olivotto, Iacopo, Bueno-Orovio, Alfonso, Sacconi, Leonardo, Coppini, Raffaele, Ferrantini, Cecilia, Regnier, Michael, Poggesi, Corrado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977265/
https://www.ncbi.nlm.nih.gov/pubmed/36744470
http://dx.doi.org/10.1161/CIRCRESAHA.122.321956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977265/
https://www.ncbi.nlm.nih.gov/pubmed/36744470
http://dx.doi.org/10.1161/CIRCRESAHA.122.321956

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