Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity. In this study, we identified that Tregs increase the quorum of self-reactive CD8(+) T cells required for t...

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Detalles Bibliográficos
Autores principales: Tsyklauri, Oksana, Chadimova, Tereza, Niederlova, Veronika, Kovarova, Jirina, Michalik, Juraj, Malatova, Iva, Janusova, Sarka, Ivashchenko, Olha, Rossez, Helene, Drobek, Ales, Vecerova, Hana, Galati, Virginie, Kovar, Marek, Stepanek, Ondrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977273/
https://www.ncbi.nlm.nih.gov/pubmed/36705564
http://dx.doi.org/10.7554/eLife.79342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977273/
https://www.ncbi.nlm.nih.gov/pubmed/36705564
http://dx.doi.org/10.7554/eLife.79342

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