MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

Loss- and gain-of-function of MeCP2 causes Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. MeCP2 binds methyl-cytosines to finely tune gene expression in the brain, but identifying genes robustly regulated by MeCP2 has been difficult. By integrating multiple transcriptomics d...

Descripción completa

Detalles Bibliográficos
Autores principales: Bajikar, Sameer S, Anderson, Ashley G, Zhou, Jian, Durham, Mark A, Trostle, Alexander J, Wan, Ying-Wooi, Liu, Zhandong, Zoghbi, Huda Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977283/
https://www.ncbi.nlm.nih.gov/pubmed/36848184
http://dx.doi.org/10.7554/eLife.83806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977283/
https://www.ncbi.nlm.nih.gov/pubmed/36848184
http://dx.doi.org/10.7554/eLife.83806

Ejemplares similares