Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication

Hepatitis E virus (HEV) is an RNA virus responsible for over 20 million infections annually. HEV’s open reading frame (ORF)1 polyprotein is essential for genome replication, though it is unknown how the different subdomains function within a structural context. Our data show that ORF1 operates as a...

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Detalles Bibliográficos
Autores principales: LeDesma, Robert, Heller, Brigitte, Biswas, Abhishek, Maya, Stephanie, Gili, Stefania, Higgins, John, Ploss, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977285/
https://www.ncbi.nlm.nih.gov/pubmed/36852909
http://dx.doi.org/10.7554/eLife.80529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977285/
https://www.ncbi.nlm.nih.gov/pubmed/36852909
http://dx.doi.org/10.7554/eLife.80529

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