Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis

Patients with nonalcoholic steatohepatitis (NASH) have increased expression of liver monocyte chemoattractant protein-1 (MCP-1), but its cellular source and contribution to various aspects of NASH pathophysiology remain debated. We demonstrated increased liver CCL2 (which encodes MCP-1) expression i...

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Detalles Bibliográficos
Autores principales: Kang, Jinku, Postigo-Fernandez, Jorge, Kim, KyeongJin, Zhu, Changyu, Yu, Junjie, Meroni, Marica, Mayfield, Brent, Bartolomé, Alberto, Dapito, Dianne H., Ferrante, Anthony W., Dongiovanni, Paola, Valenti, Luca, Creusot, Remi J., Pajvani, Utpal B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977430/
https://www.ncbi.nlm.nih.gov/pubmed/36752206
http://dx.doi.org/10.1172/jci.insight.165369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977430/
https://www.ncbi.nlm.nih.gov/pubmed/36752206
http://dx.doi.org/10.1172/jci.insight.165369

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