Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis

Patients with progressive fibrosing interstitial lung diseases (PF-ILDs) carry a poor prognosis and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis, leading to their persistence, accumulation, and excessive deposition of extracellular matrix. A complex bala...

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Detalles Bibliográficos
Autores principales: Cooley, Joseph C., Javkhlan, Nomin, Wilson, Jasmine A., Foster, Daniel G., Edelman, Benjamin L., Ortiz, Luis A., Schwartz, David A., Riches, David W.H., Redente, Elizabeth F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977433/
https://www.ncbi.nlm.nih.gov/pubmed/36752201
http://dx.doi.org/10.1172/jci.insight.163762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977433/
https://www.ncbi.nlm.nih.gov/pubmed/36752201
http://dx.doi.org/10.1172/jci.insight.163762

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