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Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis
Patients with progressive fibrosing interstitial lung diseases (PF-ILDs) carry a poor prognosis and have limited therapeutic options. A hallmark feature is fibroblast resistance to apoptosis, leading to their persistence, accumulation, and excessive deposition of extracellular matrix. A complex bala...
Autores principales: | Cooley, Joseph C., Javkhlan, Nomin, Wilson, Jasmine A., Foster, Daniel G., Edelman, Benjamin L., Ortiz, Luis A., Schwartz, David A., Riches, David W.H., Redente, Elizabeth F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977433/ https://www.ncbi.nlm.nih.gov/pubmed/36752201 http://dx.doi.org/10.1172/jci.insight.163762 |
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