Low nephron endowment increases susceptibility to renal stress and chronic kidney disease

Preterm birth results in low nephron endowment and increased risk of acute kidney injury (AKI) and chronic kidney disease (CKD). To understand the pathogenesis of AKI and CKD in preterm humans, we generated potentially novel mouse models with a 30%–70% reduction in nephron number by inhibiting or de...

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Detalles Bibliográficos
Autores principales: Good, Pamela I., Li, Ling, Hurst, Holly A., Serrano Herrera, Ileana, Xu, Katherine, Rao, Meenakshi, Bateman, David A., Al-Awqati, Qais, D’Agati, Vivette D., Costantini, Frank, Lin, Fangming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977438/
https://www.ncbi.nlm.nih.gov/pubmed/36626229
http://dx.doi.org/10.1172/jci.insight.161316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977438/
https://www.ncbi.nlm.nih.gov/pubmed/36626229
http://dx.doi.org/10.1172/jci.insight.161316

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